National Research Council (NCR) new president recently orders scientists to focus on market drivers in their research. This new order touches on many issues fundamental to science-based business. Does this make scientists more entrepreneurial? Who are these scientists who decided to take the jobs at NCR in the first place? There is a selection bias issue here: more business-driven scientists would have taken up advisory roles or become entrepreneurs themselves in new ventures because of strong IP or market incentives; and scientists do pay to be scientists because of their preference for science (read Scott Stern’s paper). The new order will force capable scientists to consider alternative institutions that value priority of discovery.